简介名称和标识符别名信息物化性质安全信息海关数据相关文献专业数据库参考化合物详情（旧版）

乐卡地平 | 100427-26-7

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中文名称：乐卡地平

英文名称： Lercanidipine

CAS No.： 100427-26-7

分子式： C₃₆H₄₁N₃O₆

分子量： 611.72724

如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击：乐卡地平结构式

PubChem CID： 65866

快速询单

乐卡地平的其他展现形式

相关杂质/同位素
相关化合物

盐酸乐卡地平

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-

CAS No.： 132866-11-6
1-溴-3,3-联苯基丙烷

(3-Bromopropane-1,1-diyl)dibenzene

CAS No.： 20017-68-9
尼群地平杂质B(EP) 标准品

3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3,5-dimethyl ester

CAS No.： 21881-77-6
去氢乐卡地平

Dehydro Lercanidipine

CAS No.： 887769-34-8
依氟鸟氨酸盐酸盐一水合物

Nitrendipine Propyl Ester

CAS No.： 225785-54-6
1,4-二氢-2,6-二甲基-3-甲氧基羰基-4-(3-硝基苯基)-吡啶-5-羧酸氯

3-Pyridinecarboxylic acid,5-(chlorocarbonyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methylester

CAS No.： 88712-56-5
5-Ethyl-demethyl Lercanidipine Hydrochloride

5-Ethyl-demethyl Lercanidipine Hydrochloride

CAS No.： 210579-71-8
Lercanidipine 5-Desmethyl-5-Propyl Ester

Lercanidipine 5-Desmethyl-5-Propyl Ester

CAS No.： 1797124-83-4

右尼古地平

3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3-[3-(4,4-diphenyl-1-piperidinyl)propyl] 5-methyl ester, (4R)-

CAS No.： 120054-86-6
3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3,5-bis[2-[methyl(phenylmethyl)amino]ethyl] ester

CAS No.： 71791-90-7
3-(1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

CAS No.： 71863-55-3
3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3-[3-(4,4-diphenyl-1-piperidinyl)propyl] 5-methyl ester

CAS No.： 102993-22-6
3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl5-[2-(1-piperidinyl)ethyl] ester

CAS No.： 108852-42-2
3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl5-[(3R)-1-(phenylmethyl)-3-pyrrolidinyl] ester, (4R)-rel-

CAS No.： 101930-02-3

简介

Lercanidipine 是一种亲脂性和具有口服活性的第三代二氢吡啶-钙通道阻滞剂 (DHP-CCB)。Lercanidipine 具有持久的降压作用和对肾脏的保护作用。

名称和标识符

MDL	MFCD00867978
InChIKey	ZDXUKAKRHYTAKV-UHFFFAOYSA-N
Inchi	1S/C36H41N3O6/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27/h7-19,22,30,33,37H,20-21,23H2,1-6H3
SMILES	O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OC(C)(C)CN(CCC(C3=CC=CC=C3)C4=CC=CC=C4)C

别名信息

- 中文别名 -

乐卡地平
1,4-双氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸 2-[(3,3-二苯丙基)甲氨基]-1,1-二甲基乙基甲酯
2-碘苯磺酸二水合物

- 英文别名 -

Lercanidipine
5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester
3-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 5-O-methyl 2,6-dimet
Lercanidipine [INN]

Lercanil (TN)
lercarnidipine
masnidipine
methyl 1,1,N-trimethyl-N-(3,3-diphenylpropyl)-2-aminoethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate
REC 15-2375
UNII-V7XTJ4R0BH
Methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O5-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] ester O3-methyl ester
CHEMBL250270
SR-01000884000
2-((3,3-DIPHENYLPROPYL)METHYLAMINO)-1,1-DIMETHYLETHYL METHYL (4RS)-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester
D08111
Q410492
3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 2-((3,3-DIPHENYLPROPYL)METHYLAMINO)-1,1-DIMETHYLETHYL METHYL ESTER
(+-)-2-((3,3-Diphenylpropyl)methylamino)-1,1-dimethylethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
A800200
SCHEMBL25268
LERCANIDIPINE [MI]
s5861
3,5-Pyridinedicarboxylic acid, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(3,3-diphenylpropyl)methylamino)-1,1-dimethylethyl methyl ester
NCGC00167492-01
100427-26-7
AC-15409
EN300-19767833
BCP21318
AKOS005571238
Lercanil
DTXSID2048327
Lercanidipine (INN)
3-(1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
SCHEMBL6846222
NCGC00167492-02
A929939
NCGC00167492-11
NS00002039
AS-75252
SR-01000884000-1
3-{1-[(3,3-diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
O5-[1-[3,3-diphenylpropyl(methyl)amino]-2-methyl-propan-2-yl] O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Lercanidipine [INN:BAN]
V7XTJ4R0BH
HMS3604G05
C13971
CHEBI:135930
LERCANIDIPINE [WHO-DD]
[2-oxo-3-(3-trifluoromethyl-phenoxy)-propyl]-phosphonic
ZDXUKAKRHYTAKV-UHFFFAOYSA-N
DB00528
SDCCGSBI-0633690.P001
HY-B0612
FT-0631006
Lercanidipine?

物化性质

实验特性

LogP	7.33040
PSA	113.69000
折射率	1.579
沸点	712.5 °C at 760 mmHg
熔点	118-120 ºC
闪点	384.7 °C
颜色与性状	白色至淡黄色固体
密度	1.177

计算特性

精确分子量	611.30000
氢键供体数量	1
氢键受体数量	6
可旋转化学键数量	14
同位素质量	611.3
重原子数量	45
复杂度	1090
同位素原子数量	0
确定原子立构中心数量	0
不确定原子立构中心数量	1
确定化学键立构中心数量	0
不确定化学键立构中心数量	0
共价键单元数量	1
疏水参数计算参考值（XlogP）	6.9
拓扑分子极性表面积	114A^2

安全信息

安全说明	H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害
风险术语	T
危害声明	H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害
警示性声明	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
储存条件	Please store the product under the recommended conditions in the Certificate of Analysis.
信号词	warning

海关数据

海关编码	2942000000
海关数据	中国海关编码： 2942000000

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专业数据库参考

PubChemId	65866

化合物详情（旧版）

SMILES

CN(CCC(C1=CC=CC=C1)C2=CC=CC=C2)CC(C)(C)OC(=O)C3C(C4=CC([N+](=O)[O-])=CC=C4)C(C(=O)OC)=C(C)NC=3C

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右尼古地平结构式

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乐卡地平 | 100427-26-7

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