Chemokine signaling pathway
趋化因子是一类分子量小的细胞因子，其主要作用是在稳态和病理条件下募集白细胞亚群。趋化因子受体表达于细胞表面，是与G蛋白偶联的7次跨膜蛋白，趋化因子就是与受体结合后传递细胞信号的。通过趋化因子受体激活G蛋白后，紧接着激活磷脂酶C（PLC）。 PLC催化磷脂酰肌醇（4,5）-二磷酸（PIP2）分解生成肌醇三磷酸（IP3）和甘油二酯（DAG），两者都是第二信使分子，可以进一步扩大细胞内信号传导; DAG激活蛋白激酶C（PKC），IP3触发细胞内储存钙的释放。二者的激活可以触发许多信号级联反应（例如MAP激酶途径），如趋化性，脱粒，超氧化物阴离子的释放以及细胞粘附分子亲和力的变化。趋化因子也是通过这种机制来诱导响应细胞定向趋化。
| Target | Antibody | Protein | ELISA Kit |
|---|---|---|---|
| GNAI3 | GNAI3 Antibody | GNAI3 Protein | GNAI3 ELISA Kit |
| GNB1 | GNB1 Antibody | GNB1 Protein | GNB1 ELISA Kit |
| GNB2 | GNB2 Antibody | GNB2 Protein | GNB2 ELISA Kit |
| GNB3 | GNB3 Antibody | GNB3 Protein | GNB3 ELISA Kit |
| GNB4 | GNB4 Antibody | GNB4 Protein | GNB4 ELISA Kit |
| GNB5 | GNB5 Antibody | GNB5 Protein | GNB5 ELISA Kit |
| GNG10 | GNG10 Antibody | GNG10 Protein | GNG10 ELISA Kit |
| GNG11 | GNG11 Antibody | GNG11 Protein | GNG11 ELISA Kit |
| GNG12 | GNG12 Antibody | GNG12 Protein | GNG12 ELISA Kit |
| GNG13 | GNG13 Antibody | GNG13 Protein | GNG13 ELISA Kit |
| GNG2 | GNG2 Antibody | GNG2 Protein | GNG2 ELISA Kit |
| GNG3 | GNG3 Antibody | GNG3 Protein | GNG3 ELISA Kit |
| GNG4 | GNG4 Antibody | GNG4 Protein | GNG4 ELISA Kit |
| GNG5 | GNG5 Antibody | GNG5 Protein | GNG5 ELISA Kit |
| GNG7 | GNG7 Antibody | GNG7 Protein | GNG7 ELISA Kit |
| GNG8 | GNG8 Antibody | GNG8 Protein | GNG8 ELISA Kit |
| GNGT1 | GNGT1 Antibody | GNGT1 Protein | GNGT1 ELISA Kit |
| GNGT2 | GNGT2 Antibody | GNGT2 Protein | GNGT2 ELISA Kit |
| GRB2 | GRB2 Antibody | GRB2 Protein | GRB2 ELISA Kit |
| GRK1 | GRK1 Antibody | GRK1 Protein | GRK1 ELISA Kit |
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